Acid camphorate of phenyldimethylpyrazolon and process of making same.



UNITED STATES PATENT EEicE.

BAPTIST REUTER, OF HCGHST-ON-THE-MAIN, GERMANY, ASSIGNOR TO THEFARBWERKE, VORM. MEISTER, LUCIUS & BRUNING, OF SAME PLACE.

ACID CAMPHORATE 0F PHENYLDIMETHYLPYRAZOLON AND PROCESS OF MAKING SAME.

SPECIFICATION forming part of Letters Patent No. 674,686, dated May 21,1901.

Application filed November 24, 1900. Serial No 37,559. (Specimens) Toall whom it may concern.-

Be it known that I, BAPTIST REUTER, Ph. D., a citizen of the Empire ofGermany, residing in Hochst-on-the-Main, Germany, have invented certainnew and useful Improvements in the Manufacture of an Acid Oamphorate ofPhenyldimethylpyrazolon, of which the following is a'speoification.

I have found that by the action ofone molecular proportion of camphoricacid on one molecular proportion of phenyldimethylpyrazolon an acidcamphorate of this base may be obtained, which possesses valuabletherapeutic properties.

The acid cam phorate of phenyldimethylpyrazolon possesses antipyreticand antihydrotic properties, just as its components. The antihydroticaction, however, is much stronger than was to be expected from itscontents of camphoric acid, while the toxic action ofphenyldimethylpyrazolon is greatly reduced.

To manufacture the acid camphorate of phenyldimethylpyrazolon, I proceedas follows:

Example: One hundred and eighty-eight kilos of phenyldimethylpyrazolonand two hundred kilos of cam phoric acid are converted into the acidsalt in the manner described in Examples I and II of my application ofthe same date herewith concerning aneutral camphorate ofphenyldimethylpyrazolon.

The acid camphorate of phenyldimethylpyrazolon is a White crystallinepowder having a melting-point of about 95 to 98 centigrade. It isreadily soluble in hot water,.

alcohol, and dilute acids and soluble with difficulty in ether, benzene,and ligroin.

The acid camphorate of phenyldimethylpyrazolon is intended for internaluse as a medicine in the form of powders, lozenges, and solutions indoses of from 0.7 to one gram for adults. It is characterized byitsvaluable antipyretic and antihydrotic properties, just as itscomponents. The antipyretic and antihydrotic action of the new compound,however, is much stronger than was to be expected from its contents ofcamphoric acid. While phenyldimethylpyrazolon has the disadvantage ofcausing a great secretion of perspiration, the new compound does nothave this efiect, but has an equally good antipyretic action;

Having now described my invention, what I claim is-- 1. Theherein-described process of making a compou [id ofphenyldimethylpyrazolon with camphoric acid, which consists in causingone molecular proportion of phenyldimethylpyrazolon to act on onemolecular proportion of camphoric acid, substantially as set forth.

2. As a new product, the acid camphorate ofphenyldimethylpyrazolon,being white crystals of a melting-point 95 to 98centigrade, readily soluble in hot water, alcohol and dilute acids,soluble with difficulty in ether, benzene and ligroin and havingantipyretic and antihydrotic properties, substantially as set forth.

In testimony that I claim the foregoing as my invention I have signed myname in presence of two subscribing witnesses.

BAPTIST REUTER.

Witnesses:

ALFRED BRISBOIS, BERNHARD LE YDEOKER.

